Veins are thin walled-structures that lack the thick, circumferential smooth muscular layer that is present in arteries. As such, peripheral veins may collapse and may be difficult to cannulate (or even locate) in patients with hypovolemia, low blood pressure, etc.
Venous return to the heart is dependent upon contraction of regional skeletal muscle (e.g. the gastrocnemius and soleus in the lower leg.) Additionally, many veins contain valves that prevent retrograde flow of blood. ( Moore, KL) If the intravenous catheter abuts one of these valves, flow of intravenous solution may be occluded. (Similiarly, valves can interfere with phlebotomy.)
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